Human IL-1 beta ELISpot Pair, 10 x 96-well

CAT#: EA101818

Human IL-1 beta ELISpot Pair, 10 x 96-well


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Specifications

Product Data
Format 10 x 96-well
Assay Type Enzyme-Linked ImmunoSpot (ELISpot)
Signal Colorimetric
Specificity Recognizes natural (pro and mature) human IL-1b
Cross Reactivity No cross reactivity with other human cytokines
Components ELISpot matched antibody pairs are extensively validated and include pre-titrated capture antibody and biotinylated detection antibody. Antibodies are supplied in quantities sufficient for 10 x 96 samples.
Background The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]
Gene Symbol IL1B
Gene ID 3553

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