SARS-CoV-2 - Leflunomide - Therapeutic Candidates

SARS-CoV-2 - Leflunomide - Therapeutic Candidates


Leflunomide is an immunosuppressant used as a disease-modifying drug for rheumatoid arthritis and psoriatic arthritis. Immunosuppressants are drugs that decrease the immune system and chronic inflammation of the joints. Leflunomide has an anti-rheumatic effect with a slow onset of action. It works by stabilizing the overactivity of immune system cells that cause inflammation of the joints. To do this, leflunomide inhibits the mitochondrial enzyme dihydroorotate dehydrogenase (DHOH) which plays a key role in the synthesis of uridine monophosphate (rUMP), necessary for the synthesis of DNA and RNA. 
A study to examine the tolerability of high doses of leflunomide in patients with COVID-19 who are not yet hospitalized, but who have risk factors for disease progression and complications, has begun. In vitro studies have shown the antiviral effects of leflunomide against CoV-2-SARS. The hypothesis of this study is that targeting high-risk patients earlier in disease progression and a higher dose of leflunomide are necessary to see an improvement in disease outcome with COVID-19.

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RUOCE / IVD
  • Unconjugated 24
  • Biochemicals 87
  • Inhibitor/Antagonist/Agonist 37
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NB-48-0547-50MG
 50mg 
orb134638-100mg
 100mg 
orb1904067
 10mm 
orb1904068-100mg
 100mg 
orb1309564-500mg
 500mg 
orb1309564-50mg
 50mg 
orb1224060-200mg
 200mg 
orb1309564-25mg
 25mg 
orb322557-500mg
 500mg 
orb322557-100mg
 100mg 
orb546044-50mg
 50mg 
orb322557-1g
 1g 
orb134638-250mg
 250mg 
orb546044-250mg
 250mg 
orb1309564-100mg
 100mg 
orb1904066-500mg
 500mg 
orb1224060-25mg
 25mg 
orb1224060-100mg
 100mg 
orb1224060-50mg
 50mg 
orb1309564-200mg
 200mg