Sambucus nigra Lectin (SNA/EBL I+II)

Sambucus nigra Lectin (SNA/EBL I+II)


Sambucus nigra lectin (EBL I+II, also known as SNA) is isolated from elderberry bark. This lectin has a molecular weight of 140 kDa and is composed of two ricin-related lectins. EBL I+II is a tetrameric glycoprotein with a recognition of the Neu5Ac(alpha2-6)Gal or GalNAc linkage in glycoconjugates.
EBL I+II is not blood group specific but it does agglutinate type A erythrocytes more strongly than either B or O cells. Trypsin treated erythrocytes react better than untreated cells. Neuraminidase treated erythrocytes react with this lectin due to the presence of terminal galactose resides.
EBL I is composed of an A-chain with enzymatic activity and a B-chain with carbohydrate-binding activity. EBL II consists only of carbohydrate-binding B-chains. EBL I+II induces caspase-dependent apoptosis at low concentrations (nM) order, leading to typical symptoms of cell death in sensitive cells. This effect seems independent from the catalytic activity of the A-chain, but depends on the carbohydrate binding B-chain.

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Description
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L1237-5
 5mg 
L1237-10
 10mg 
L1237-50
 50mg 
MBS656204-1mg
 1mg 
MBS656372-5mg
 5mg 
MBS656372-5x5mg
 5x5mg 
MBS656204-5x1mg
 5x1mg 
MBS656332-1mg
 1mg 
MBS656332-5x1mg
 5x1mg 
MBS655862-1mg
 1mg 
MBS656077-1mg
 1mg 
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